Interaction of Lipids with Voltage-Gated Ion Channel Proteins
نویسندگان
چکیده
منابع مشابه
Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins.
Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis methods. In this study, we have used a profile-to-profile alignment method to identi...
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Commentary The voltage-gated potassium channel subunit Kv4.2 is a pore-forming alpha subunit of A-type potassium channels. Kv4.2, encoded by the KCND2 gene, is broadly expressed in the central nervous system and is predominantly localized on neuronal dendrites, with increased density on distal dendrites (1). A-type potassium channels are important regulators of neuronal excitability, modulating...
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Calcium ions play a primary role in the regulation of sperm cell behavior. We report finding a voltage-gated ion channel (CatSper2) that is expressed in male germ cells but not in other cells. The putative channel contains 6 transmembrane segments, making it more similar to the voltage-gated potassium channels, but the ion selectivity pore domain sequence resembles that of a Ca(v) channel. The ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.917